Multiscale modeling in computational biomechanics

Multiscale modeling methods in biomechanics

More and more frequently, computational biomechanics deals with problems where the portion of physical reality to be modeled spans over such a large range of spatial and temporal dimensions, that it is impossible to represent it as a single space-time continuum. We are forced to consider multiple space-time continua, each representing the phenomenon of interest at a characteristic space-time sc...

Multiscale modelling in biomechanics

Computational multiscale modeling of embryo development.

Recent advances in live imaging and genetics of mammalian development which integrate observations of biochemical activity, cell-cell signaling and mechanical interactions between cells pave the way for predictive mathematical multi-scale modeling. In early mammalian embryo development, two of the most critical events which lead to tissue patterning involve changes in gene expression as well as...

Integrative Computational Frameworks for Multiscale Digital Human Modeling and Simulation

Integrated digital human modeling has seen increased interest over the last decade. We describe two efforts to develop computational frameworks for digital human modeling and describe the progress toward understanding the requirements for implementation. Both projects addressed data repository, computational environment, and visualization of results. But neither environment was a true problemso...

On the multiscale modeling of heart valve biomechanics in health and disease.

Theoretical models of the human heart valves are useful tools for understanding and characterizing the dynamics of healthy and diseased valves. Enabled by advances in numerical modeling and in a range of disciplines within experimental biomechanics, recent models of the heart valves have become increasingly comprehensive and accurate. In this paper, we first review the fundamentals of native he...